Category Archives: Medications

Proposed Reclassification of Hydrocodone as a Schedule II substance

The DEA had asked FDA to recommend the Schedule II reclassification that would limit refills to a 90-day supply instead of the current five refills within six months, because of the potential for abuse.

“The restrictions may make it tougher for pain patients. In some states, nurse practitioners can’t write prescriptions for Schedule II drugs and many doctors aren’t willing to prescribe anything stronger than Schedule III”, said Edward Michna, assistant professor at Harvard Medical School, and director of the Pain Trials Center at Brigham and Women’s Hospital in Chestnut Hill, Massachusetts.

And just for comparison, cannabis a Schedule I substance.

[Wikipedia] Hydrocodone/paracetamol (also known as hydrocodone/acetaminophen, hydrocodone/APAP or under brand names such as Lortab, Norco or Vicodin) is a combination narcotic analgesic drug consisting of hydrocodone and paracetamol (acetaminophen) used to relieve moderate to severe pain.

Development of new pain-killing drugs that are not addictive

US and Australian research team which has made a breakthrough in revealing how opioid drugs such as morphine both relieve pain and also cause addiction.

The scientists tested a new drug called AV411 that blocks morphine’s effects on glia cells but not on neurons, resulting in effective pain relief without the side effects of addiction.

Currently, AV411 is in clinical trials at the Royal Adelaide Hospital. And it is being developed by Avigen Inc., a Californian biopharmaceutical company.

University of Adelaide (2007, November 23). Strong Pain-killing Drugs Without The Addiction. ScienceDaily. Retrieved November 24, 2007, from http://www.sciencedaily.com/releases/2007/11/071123210617.htm

Oxytrex – better than oxycodone?

Pain Therapeutics said it would start testing Oxytrex in the second half of 2007, enrolling into the “Extreme Study” about 120 patients who depend on large daily doses of oxycodone — or doses greater than or equal to 120 mg — to treat severe chronic pain, whom the company said are particularly prone to physical dependence and withdrawal.

There is reason to believe that Oxytrex will produce greater analgesia, while producing lower levels of tolerance and dependence, than oxycodone.


Pain Therapeutics website.

About Oxytrex from Pain Therapeutics, Inc.

“Oxytrex is a unique oral painkiller that preferentially inhibits an excitatory effect of opioid receptors. This excitatory effect is believed to counteract analgesia (pain relief) and cause tolerance. Its inhibition enhances pain relief and minimizes opioid tolerance. We believe Oxytrex represents the first new mechanism of action by an opiate drug since morphine was discovered over 100 years ago.

We are developing Oxytrex to treat moderate-to-severe chronic pain, such as osteoarthritic pain or low-back pain. We believe Oxytrex could be an effective substitute for oxycodone, a leading opioid painkiller, with U.S. sales of nearly $2 billion for the 12-months ending August 2005, according to IMS Health data.”

Ultram ER

Ultram ER (tramadol HCl) is the first extended release tramadol product approved in the United States for relief of moderate to moderately severe chronic pain in adults who require around-the-clock treatment of their pain for an extended period of time. Ultram ER is available in once-daily dosage strengths of 100 mg, 200 mg and 300 mg tablets.

The U. S. Food and Drug Administration (FDA) approved Ultram ER in September 2005 based on clinical and safety data obtained from four well- controlled clinical trials. More than 3,000 patients have been treated with Ultram ER in clinical trials.

Tramadol is a non-scheduled centrally-acting synthetic opioid analgesic that has been used in the treatment of moderate to moderately severe pain since its introduction in the United States in 1995. Ultram ER uses Biovail’s innovative Smartcoat(TM) technology* to produce an extended-release tablet that provides appropriate patients effective pain control over a 24-hour period in a convenient once-daily form of tramadol. In contrast, patients may need to take immediate release tramadol tablets every 4-6 hours for pain relief.

Ultram ER is contraindicated in any situation where opioids are contraindicated, including in those patients with a history of anaphylactoid reactions to opioids.

Seizures have been reported in patients receiving tramadol. The risk of seizure is increased with doses of tramadol above the recommended range and in patients taking certain medications such as tricyclic antidepressants, selective serotonin reuptake inhibitors or opioids. Administration of tramadol may enhance the seizure risk in patients taking MAO inhibitors, neuroleptics, other drugs that reduce the seizure threshold, or in patients with epilepsy, those with a history of seizures, or in patients with a recognized risk for seizure (such as head trauma, metabolic disorders, alcohol and drug withdrawal, CNS infections).

Tramadol, like other opioids used in analgesia, can be abused. Ultram ER should not be used in patients who are suicidal or addiction-prone, or taken with alcohol-containing beverages.

In clinical trials the most frequently reported side effects associated with Ultram ER were dizziness, nausea, constipation, somnolence, and flushing.

Ultram ER Extended-Release Tablets are intended for oral use only and should be swallowed whole. The tablets should not be chewed, crushed, or split.

Ultram ER should not be administered at a dose exceeding 300 mg per day.

On the Net

ortho-mcneil.com
ultram-er.com/
Ultram description on medicinenet.com
Ultram description on opioids.com

Strange treatment for back pain

An Oregon woman suing her doctor and his medical clinic for $4 million. She said that his medical treatment included intercourse which was needed to help alleviate her lower back pain.

The doctor, Randall Smith, was stripped of his license and sent to jail for 60 days last year for charging the stateís Oregon Health Plan $5,000 for his 45-minute ìtreatmentsî involving the woman.


Are people are too willing to sue over mistakes they make themselves?

On The Net

Doctor sued over sex treatment for back pain (MSNBC)

Randall Smith short bio